CLINICAL AND GENOMIC CHARACTERIZATION OF CHEMORADIATION-RESISTANT HPV-POSITIVE OROPHARYNGEAL SQUAMOUS CELL CARCINOMA

Clinical and genomic characterization of chemoradiation-resistant HPV-positive oropharyngeal squamous cell carcinoma

IntroductionMost patients with HPV-positive oropharyngeal squamous cell carcinoma (OPSCC) have an excellent response to chemoradiation, and trials are now investigating de-escalated treatment.However, up to 25% of patients with HPV-positive OPSCC will experience recurrence, and up to 5% will even progress through primary treatment.Currently, there

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Effects of increased nitrogen deposition and rotation length on long-term productivity of Cunninghamia lanceolata plantation in southern China.

Cunninghamia lanceolata (Lamb.) Hook.has been widely planted in subtropical China to meet increasing timber demands, leading to Gifts short-rotation practices that deplete soil nutrients.However, increased nitrogen (N) deposition offsets soil N depletion.While long-term experimental data investigating the coupled effects related to short rotation p

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Classification of tools for reducing corruption risks in the system of public procurement, depending on their impact on the factors of corruption R. Klitgaard

Importance.The development of tools to reduce corruption risks in the procurement system to ensure public needs (public procurement) is an important state task.The current state of public procurement indicates the presence in this area: firstly, contradictions between the anticorruption target of creating a modern public procurement system and the

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